Results 221 to 230 of about 312,698 (293)

Analyses of astrocyte-neuron lactate shuttle transporter levels in brain tissues from people with HIV-associated neurocognitive impairment and Alzheimer's disease. [PDF]

NeuroImmune Pharm Ther
Boustani A, Laird A, Shu L, Sundermann EE, Moore DJ, Rissman R, Fields JA.   +6 more
europepmc   +1 more source

The Elephant Trunk Skin Inspires a Highly Sensitive and Deformable, Yet Robust, Armor Skin

Advanced Science, EarlyView.
The study presents the elephant trunk‐inspired armor skin with tactile sensing (ETATS). The ETATS architecture stretches and compresses while resisting puncture and tear, and it enables optical detection of pressure and lateral strain. Morphology‐based decoupling of strain and pressure paves the way to sensitive and deformable, yet robust, soft‐robotic
Jun Chang Yang, Petr Trunin, Behnam Kamare, Lucia Beccai   +3 more
wiley   +1 more source

N⁶-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93. [PDF]

Nat Cell Biol
Lee JH, Lee JH, Tingey M, Zhang Z, Buerger F, Hong J, Zhang G, Yang M, Du B, Jeong JH, John KA, Tamayo IM, Zhao QD, Hildebrandt F, Đurišić M, Stajić N, Spasojević B, Yang W, Xu K.   +18 more
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Activation of FCGR2A enhances the antitumor efficacy of hPSC-derived CAR-M. [PDF]

Front Cell Dev Biol
Yang X, Li L, Zhu S, Li S, Wang X, Han Y, Yang L.   +6 more
europepmc   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Ferroptosis in microglial activation: a systematic review and multidata comparison. [PDF]

Brain Commun
Pesämaa I, Koutarapu S, Zetterberg H, Fruhwürth S.   +3 more
europepmc   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2. [PDF]

J Cell Sci
Shrestha BK, Sjøttem E, Olsvik HL, Odonkor I, Øvervatn A, Brenne HB, Bruun JA, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source