Results 91 to 100 of about 6,089,774 (311)

Eurasian Call for the Project «Integration of Integrations»

open access: yesУправленческое консультирование, 2018
In today’s rapidly changing world integration is one of the possibilities of sustainable development of countries, and in view of the growing role of large state associations, increasing the likelihood of integration project.
Nikolai Maratovich Mezhevich
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

CONSEQUENCES OF THE JULY (2025) EU–US AGREEMENT FOR GERMANY’S ECONOMIC AND POLITICAL SPACE

open access: yesНаучно-аналитический вестник Института Европы РАН
The article analyzes the implications for Germany’s economic Standort of the agreements reached between the European Union and the United States on July 27, 2025, in Scotland. European Commission President Ursula von der Leyen and U.S.
Vladislav B. Belov
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

India's foreign policy: main strategic directions

open access: yesСовременная наука и инновации
The article deals with the problem of the formation of strategic directions of India's foreign policy, since the modern foreign policy of India is determined precisely by the need to overcome geographical and geopolitical isolation.
M. M. Abazalieva, A. Yu. Belokon
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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