Results 81 to 90 of about 6,089,774 (311)

Ekonomik Güvenlik Politikalarında Yeni Trendler: ABD, Avrupa Birliği ve Japonya

open access: yesUluslararası Ekonomi, İşletme ve Politika Dergisi
Bu çalışmada küresel ekonominin başat aktörleri olarak ABD, Avrupa Birliği (AB) ve Japonya’nın ekonomik güvenliğe ilişkin strateji ve politikaları incelenmektedir.
Halil İbrahim Kaya, Güven Delice
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

La rielezione di Obama. Un'analisi del voto presidenziale 2012 negli Stati Uniti

open access: yesQOE-IJES, 2012
This article analyzes the 2012 American Presidential election. It is divided into five sections. The first one is focused on data and numbers of electoral results. The second reflects upon the nature of the Electoral College.
Marco Morini
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Indonesian Regional Policy in the Focus of National Research Schools: А Сomparative Analysis

open access: yesVestnik RUDN. International Relations
Indonesia is the largest country in Southeast Asia, which has a serious impact on international processes in the region. At the same time, Indonesia’s foreign policy is shaped by a number of external and internal factors.
Kirill S. Kablukov
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Amerikan Diplomasisinde Değişimin ve Manevi Motivasyonun Sürekliliği:Soğuk Savaş Dönemi Örneği

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018
Sömürgeciliğe karşı mücadele ile kurulan ilk devlet olma vasfını taşıyan Amerika Birleşik Devletleri ABD ; sırasıyla kıtasal, bölgesel ve küresel genişlemesi neticesinde mevcut konumuna ulaşmıştır.
Metin Aksoy, Yasin Avcı
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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