Results 131 to 140 of about 5,933,393 (275)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Publisher Correction: Best practice recommendations and considerations for designing and electronically implementing event-driven diaries in clinical trials. [PDF]

NPJ Digit Med
Mowlem FD, Trudeau JJ, Platko JV, Bloemers J, Flood E, Abel JL, Dumais K, O'Donohoe P, Grant S, Naville-Cook R, Illoh O, Keith SD, Ju J, Fitter M, Oberdhan D, Winnette R, Bossi M, Suminski N, Eremenco S, Hughes L, Fasiczka A, Rojas L, Campbell M, Kern S, Electronic Clinical Outcome Assessment Consortium, Patient-Reported Outcome Consortium.   +25 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Strandline records of high frequency, low magnitude drops in water level, glacial Lake Agassiz basin, Central Polk County, MN, USA

Maureen Casaus, Timothy G. Fisher, Harry M. Jol, Kenneth Lepper   +3 more
openalex   +1 more source

Neue Daten zur Demographie und Selbstidentifikation unter Juden in den USA : Trends, Unstimmigkeiten und unterschiedliche Auffassungen

, 1994
Sergio DellaPergola
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Access in all areas? A round-up of developments in market access and health technology assessment: part 10

Journal of Comparative Effectiveness Research
In this update, we examine the US’ Food and Drug Administration (FDA) Commissioner’s National Priority Voucher pilot program; The Netherlands’ Zorginstituut Nederland (ZIN) implementation framework for the EU HTA Regulation; and Italy’s Agenzia ...
Sreeram V Ramagopalan, Annie Jullien Pannelay   +1 more
doaj   +1 more source

Author Correction: A streamlined base editor engineering strategy to reduce bystander editing. [PDF]

Nat Commun
Valdez I, O'Connor I, Patel D, Gierer K, Harrington J, Ellis E, Caponetti SA, Sebra RP, Valley HC, Coote K, Mense M, Marro SG, Jiang T.   +12 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Survey of Doctoral Programs in IS in the USA and Canada.

, 2010
Stephen Larson
openalex   +2 more sources