Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Author Correction: Nutrient loading as a key cause of short- and long-term anthropogenic ecological degradation of the Salton Sea. [PDF]
Hung C+8 more
europepmc +1 more source
Varietal changes in two Finnish alsike clover varieties grown for seed in the USA
Otto Valle+2 more
openalex +2 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Correction: Posterior Fixation and Fusion (PFF) versus Combined Anterior and Posterior Fixation and Fusion (CAPFF) for type B and C thoracolumbar spine injuries: a systematic review and meta-analysis. [PDF]
Mkochi VL+4 more
europepmc +1 more source
Effects of social and demographic factors on poverty among adult males in the USA
Thomas T. H. Wan
openalex +2 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Letter to the Editor: Reply to "Population Screening for Cirrhosis" by Thiele et al, describing the Florida Healthy Liver Program. [PDF]
Ryland KL+8 more
europepmc +1 more source