Results 261 to 270 of about 12,310,007 (328)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Residing in a low-income-low-food-access neighbourhood and asthma in early and middle childhood in the Environmental influences on Child Health Outcomes (ECHO) program: a multisite cohort study. [PDF]

BMJ Open
Wang VA, Habre R, Ryan PH, Datta S, Luttmann-Gibson H, Blossom J, Aris IM, Chandran A, Kress AM, Gilliland F, Breton C, Farzan SF, Camargo CA, Liang D, Kerver JM, Karr CJ, Leve LD, Dabelea D, Karagas MR, Bennett DH, Nkoy FL, Aschner J, O'Shea TM, McEvoy CT, Knapp EA, Schuh HB, Miller RL, Gold DR, Zanobetti A, ECHO Cohort Consortium.   +29 more
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Innovations at the intersection of homelessness and substance use during the COVID-19 pandemic: a scoping review. [PDF]

Harm Reduct J
Passmore H, Craft S, Krieger R, Tang S, Sacerdote S, Lumbis E, Blaufarb S, Doran KM.   +7 more
europepmc   +1 more source

National Coal Utilization Assessment: a preliminary assessment of coal utilizaton in the South. [Southern USA to 2020; forecasting]

, 1978
Luke Berry, D.J. Bjornstad, F. D. Boercker   +2 more
openalex   +2 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Semi-automated tortuosity measurements confirm generalizability of IMPERATIVE trial results to real-world patients with acute ischemic stroke undergoing thrombectomy.

Interv Neuroradiol
Mokin M, Mack WJ, Nogueira RG, Grossberg JA, Majidi S, Tomalty D, Vargas J, Cucchiara BL, Snyder KV, Mascitelli JR, Parada V, Shakir HJ, Rosenbaum-Halevi D, Aghaebrahim N, Hoit D, Yim B, Tenser MS, Al-Bayati AR, Milburn JM, Nimjee SM, Haranhalli N, Nahhas M, Shaff DI, Layton KF, Beaty NB, Starke RM, Hawk H, Haussen DC, Pabaney A, Kellner CP, De Leacy RA.   +30 more
europepmc   +1 more source

Correction to: Endocarditis in Adult Congenital Heart Disease Patients: Prevention, Recognition, and Management. [PDF]

Curr Cardiol Rep
Carvajal V, Reyes FB, Gonzalez D, Schwartz M, Whitlow A, Alegria JR.   +5 more
europepmc   +1 more source

Entwicklungsnationalismus und Kompradorenpolitik. Die Gründung der OAS und die Entwicklung der Abhängigkeit Lateinamerikas von den USA

, 1978
Lothar Brock
openalex   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source