Results 91 to 100 of about 59,675,237 (384)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Strategies to design for dynamic usability [PDF]
, 2009 Since usability is a property of the interaction between a product, a user and the task that he or she is trying to complete [6], a product’s usability can vary when it is used in varying use situations. We define this as dynamic usability. This study is
Bijl-Brouwer, Mieke van der +1 more
core +2 more sources
Evaluating usability of cross-platform smartphone applications [PDF]
, 2014 The computing power of smartphones is increasing as time goes. However, the proliferation of multiple different types of operating platforms affected interoperable smartphone applications development. Thus, the cross-platform development tools are coined.
Ghinea, G +3 more
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Media and Communication, 2017 Social media (SoMe) platforms provide potentially important information for news journalists during everyday work and in crisis-related contexts. The aims of this study were (a) to map central journalistic challenges and emerging practices related to ...
Klas Backholm +6 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Buildings, 2019 Visualizing building assets within building information modeling (BIM) offers significant opportunities in facility management as it can assist the maintenance and the safety of buildings.
Romain Neuville +2 more
doaj +1 more source
, 2015 Perceived usability affects greatly student’s learning effectiveness and overall learning experience, and thus is an important requirement of educational software.
Konstantina Orfanou +2 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source