Results 111 to 120 of about 391,908 (294)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Assessing the memorability and usability of the Gutenberg Editor Interface in the Drupal CMS

Journal of Computer Sciences Institute
The study was conducted with the participation of 8 online editors with no previous experience with the Drupal system. The subjects performed a series of tasks in 3 sessions spread over time.
Paweł Iwon, Marek Miłosz
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Usability als Beruf - Ergebnisse einer Umfrage unter Usability Professionals

, 2007
Mit steigender Popularität des Themas hat sich das Beschäftigen mit Usability (Gebrauchstauglichkeit, SoftwareErgonomie) zum eigenständigen Berufsbild entwickelt.
Diefenbach, Sarah, Hassenzahl, Marc
core   +1 more source

Integrating Telemedicine in Botulinum Toxin Type-A Treatment for Spasticity Management: Perspectives and Challenges from Italian Healthcare Professionals

Toxins
(1) Background: Telemedicine is a vital tool for enhancing healthcare accessibility and outcomes at reduced costs. This study aimed to assess the usability of the Maia Connected Care telemedicine platform for managing spasticity in patients receiving ...
Stefania Spina, Salvatore Facciorusso, Nicoletta Cinone, Luigi Santoro, Anna Castagna, Marina Ramella, Franco Molteni, Andrea Santamato, The Collaborative Working Group   +8 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Exploring the Usability of Municipal Web Sites: A Comparison Based on Expert Evaluation Results from Four Case Studies [PDF]

The usability of public administration web sites is a key quality attribute for the successful implementation of the Information Society. Formative usability evaluation aims at finding and reporting usability problems as early as possible in the ...
Costin PRIBEANU, Ruxandra-Dora MARINESCU, Dragos Daniel IORDACHE, Maria GHEORGHE-MOISII   +3 more
core  

Generative AI in Education: Assessing Usability, Ethical Implications, and Communication Effectiveness

Societies
The rapid expansion of generative artificial intelligence tools for textual production, such as ChatGPT, has been accompanied by a proliferation of similar tools used for creating images, audiovisual content, and motion graphics.
Maria Matsiola, Georgios Lappas, Anastasia Yannacopoulou   +2 more
doaj   +1 more source