Results 111 to 120 of about 59,675,237 (384)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Useful to Usable: Developing usable climate science for agriculture
Climate Risk Management, 2017 AbstractThe Useful to Usable (U2U) project was a six-year research and extension project funded by the United States Department of Agriculture to provide both useful and usable climate information for the agricultural (corn) sector in the Midwestern United States.
Prokopy, Linda S +5 more
openaire +5 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Access and usability issues of scholarly electronic publications [PDF]
, 2004 This chapter looks at the various access and usability issues related to scholarly information resources. It first looks at the various channels through which a user can get access to scholarly electronic publications.
Chowdhury, G.
core
, 2012 Adequate usability is important because it is a characteristic of product quality that leads to improving product acceptability, increasing user satisfaction, improving product reliability and it is also financially beneficial to companies. Such benefit can be seen from two points of view, one related with workers’ productivity (less training time and ...
Isabel L. Nunes, Mário Simões-Marques
openaire +4 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
From usability to secure computing and back again [PDF]
, 2019 Secure multi-party computation (MPC) allows multiple parties to jointly compute the output of a function while preserving the privacy of any individual party’s inputs to that function. As MPC protocols transition from research prototypes to realworld
Albab, Kinan Dak +7 more
core +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Security and Online learning: to protect or prohibit [PDF]
, 2003 The rapid development of online learning is opening up many new learning opportunities. Yet, with this increased potential come a myriad of risks. Usable security systems are essential as poor usability in security can result in excluding intended users ...
Adams, Anne, Blandford, Ann
core +1 more source
Models for universal usability [PDF]
Proceedings of the 15th French-speaking conference on human-computer interaction on 15eme Conference Francophone sur l'Interaction Homme-Machine - IHM 2003, 2003 This paper discusses how model-based approaches can support designers and developers to address a number of challenges raised by universal usability, such as the possibility of obtaining user interfaces able to adapt to any device and usability evaluation tools able to ana-lyse any users who can be located anywhere.
openaire +4 more sources