Results 191 to 200 of about 134,387 (234)

A Telehealth-Based Behavioral Intervention for Cancer-Related Cognitive Decline in Older Adults Undergoing Systemic Therapy for Breast Cancer: Development and Usability Testing. [PDF]

JMIR Form Res
Kelly JM, Berkhof L, Franco-Rocha OY, Mustian L, Targia V, Bauer J, Mortimer J, DiGiovanni G, Millstein D, Scioli K, DAurizio H, DeCaporale-Ryan L, Mohile S, Janelsins M, Ferguson RJ, Huston A, Magnuson A.   +16 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Assistive Robotic Arm to Support Activities of Daily Living in Individuals With Tetraplegia: Protocol for a Real-World Convergent Parallel Mixed Methods Feasibility Study.

JMIR Res Protoc
Fosbrooke V, Christen A, Wortmann BC, de Boer ITM, Rätz R, Rösch JF, Gruener G, Raab AM.   +7 more
europepmc   +1 more source

The Impact of Healthcare Professionals' Characteristics on the Evaluation of Clinical Decision Support Systems: Insights from a Cross-Country Usability and Technology Acceptance Study of the iCARE Tool. [PDF]

J Med Syst
Nuutinen M, Hiltunen AM, Leskelä RL, Messo M, Salminen A, Lahelma M, de Almeida Mello J, Declercq A, Švihnosová O, Langmaierová K, Fialová D, Mammarella F, Liperoti R, Exmann C, van Hout H, Pešić V, Howard E, Stodolska A, Szczerbińska K, Alon M, Haavisto I.   +20 more
europepmc   +1 more source

Usability and Cultural Relevance of an mHealth App for Hispanic/Latino Individuals Living With Rheumatoid Arthritis: Protocol for a Mixed Methods Study. [PDF]

JMIR Res Protoc
Alves TF, Horner R, Montas MC, Cozad M.
europepmc   +1 more source

Technological Strategies for the Patient Experience in Emergency Departments: Scoping Review.

JMIR Med Inform
Santafé AS, Aranda JM, Beltrán WJ, Guerrero WJ, Guevara Lozano M, Bustos IX.   +5 more
europepmc   +1 more source

Usability Evaluation of the Karafs Application: A Qualitative Study Using the Think-Aloud Method. [PDF]

Health Sci Rep
Bohlouly F, Kheirdoust A, Ghaddaripouri K, Sheibani R, Mazaheri Habibi MR.   +4 more
europepmc   +1 more source