Results 181 to 190 of about 698,130 (295)

Developing a Cross-Device Platform for Robotic Systems in Nursing Care: Mixed Methods Feasibility Study. [PDF]

JMIR Nurs
Müller P, Veit R, Hofstetter S, Jahn P.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Usability of iSupport Swiss, a World Health Organization Digital Intervention for Caregivers of People With Dementia: Mixed Methods Study.

J Med Internet Res
Messina A, Amati R, Annoni AM, Albanese E, Fiordelli M.   +4 more
europepmc   +1 more source

Telerehabilitation Following Stroke: Development of Training Content and Evaluation of an App-Based Training Program. [PDF]

JMIR Rehabil Assist Technol
Ziller C, Gäumann S, Lüscher S, Paulissen N, Behrendt F, Suica Z, Crüts B, Gamerschlag L, Parmar K, Gerth HU, Bonati LH, Schuster-Amft C.   +11 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Improving Usability of the Interrupting Prolonged Sitting With Activity Virtual Teacher Training Modules: Case Study.

JMIR Hum Factors
Hasson RE, Tam T, Myers L, Schwartz A, Li A.   +4 more
europepmc   +1 more source

Usability Validation of an Integrated Hemodynamic and Pulmonary Monitoring System Using Eye-Tracking Analysis. [PDF]

J Clin Med
Jeong H, Choi H, Kim H, Jang W.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Technical & clinical evaluation of a novel slim gastroscope in third-space procedures: Feasibility, subjective workload & system usability assessment. [PDF]

Endosc Int Open
Cahyadi O, Torres Reyes C, Ayoub M, Quast D, Ewald P, Ebigbo A.   +5 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source