Results 161 to 170 of about 144,275 (268)

Human factors validation study of an artificial neural network‑based preoperative decision‑support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN99301435). [PDF]

BMC Cancer
Allfelt A, Bendahl PO, Dihge L, Ohlsson M, Rydén L, Skarping I.   +5 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Design and content of health facility routine data recording and reporting forms for maternal, newborn, and child health: a scoping review of literature. [PDF]

JAMIA Open
Peeler A, Hammerich-Hille S, Muzigaba M, Peeler M, Sakuma Y, Gerlach N, Correia R, Diaz T, Katwan E, Day LT.   +9 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Towards a feature-based regulatory benchmark for user-centred SaMD design in cancer care. [PDF]

BMJ Health Care Inform
Kheirinejad S, Brett CL, Davis RL, Schwartz DL, Shaban-Nejad A.   +4 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Kalmer, a specific based-App intervention for the treatment of Non-suicidal self-injury (NSSI): a technical and usability study in a non-clinical population. [PDF]

Front Digit Health
Conesa Giménez M, Jaén I, Vega D, Julià A, López-Solà M, Solé-Casals J, Miralles I, Garcia-Palacios A.   +7 more
europepmc   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Predicting Electronic Health Record Usability: Scoping Review of Adoption Models, Metrics, and Future Directions. [PDF]

JMIR Hum Factors
Chrimes D, Thomo A, Kuo MA, Borycki EM, Kushniruk A.   +4 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source