Results 151 to 160 of about 391,908 (294)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Development and Initial Usability Evaluation of SSEndoSim, a Free, Web-Based Endodontic Diagnostic Simulator: Cross-Sectional Study. [PDF]

JMIR Hum Factors
Suresh S, Rani P, Kalhoro F.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Zertifizierung von Usability Experten

, 2006
Thema des Beitrags ist die Zertifizierung von Usability Experten. Da nach wie vor geeignete Ausbildungs- und Studiengänge in Deutschland fehlen, gibt es ein Interesse an einem Nachweis bzw. dem Erwerb von Kenntnissen zum Thema Usability.
Beck, Astrid, Petrasch, Roland
core  

Evaluation of smart TV user interfaces for older adults based on the perception assessment method of analytic hierarchy process (AHP)-fuzzy theory. [PDF]

Front Psychol
Zhang T, Me RC, Alli H.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Executive Dysfunction-A Serious Game for Assessment in Real-Life Contexts: Development and Cross-Sectional Usability Study. [PDF]

JMIR Serious Games
Olivares D, Martínez-Pernía D, Olavarría L, Cerda M, Montenegro D, Ramírez C, Nieto R, Farías G, Slachevsky A.   +8 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Branchenreport Usability 2009

, 2009
Mit steigender Bekanntheit des Themas Usability wächst auch das Interesse an Informationen zur Arbeitssituation, Ausbildungswegen und Verdienstmöglichkeiten von Usability Professionals – Aufgabe des Berufsverbands der deutschen Usability Professionals ...
Diefenbach, Sarah
core  

User-Centered Design of an Electronic COPD Patient Questionnaire for Clinical Decision Support. [PDF]

Int J Chron Obstruct Pulmon Dis
Kouri A, Garzouzi Z, Chudyk AM, Singer A, Butler SJ, Ross BA, Gupta S.   +6 more
europepmc   +1 more source