Results 41 to 50 of about 698,688 (236)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Development of methodology of alternative rationale for financial ensuring of bridges building [PDF]
, 2020 The purpose of the article is to develop a methodology for alternative substantiation of financial support for bridge construction. To achieve the purpose, the following general scientific and special methods and techniques of research were used: “golden
Bezpartochnyi, Maksym +2 more
core
Identifying psychological and socio-economic factors affecting motorcycle helmet use [PDF]
, 2015 Sixty percent of motorcyclist fatalities in traffic accidents of Iran are due to head injuries, but helmet use is low, despite it being a legal requirement.
Groeger, John A. +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Lithic Studies, 2016 The Middle Palaeolithic site of Lagoa do Bando is an open air site in a lacustrian context located at 570 m a.s.l. in the municipality of Mação in the center of Portugal.
Gabriele Luigi Francesco Berruti +1 more
doaj +1 more source
Поволжская археология, 2020 The paper presents the first results of comprehensive studies of the hunting and hunting weapons of the Neanderthals during the Middle Paleolithic in the Elbrus region in the Northern Caucasus.
Doronicheva Ekaterina V. +4 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Археология евразийских степейAs a result of the excavations of the Sholma I site on the Tsivil River (right bank of the Volga, Chuvashia), carried out by the authors in 2007, 2011 and 2017, a significant assemblage of nuclei, plates and tools was obtained.
Madina Sh. Galimova +3 more
doaj +1 more source
Open Archaeology, 2022 It is well known that many Mesolithic and Early Neolithic sites were uncovered during the past century in the Iron Gates region of the North-Central Balkans.
Petrović Anđa +3 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source