Results 51 to 60 of about 17,512,953 (347)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Local Variations in Swordsmanship
Danish Journal of ArchaeologyThis study is centered around local variations in swordsmanship in Bronze Age Denmark. This is studied through Metalwork Wear Analysis (MWA) of eight Early Bronze Age swords and one spearhead from Jutland, three of which were studied in greater detail ...
Gustav Solberg +1 more
doaj +1 more source
Przegląd Archeologiczny, 2021 The specific relationship between weapon-form and mode of use has become a subject of intense research regarding the martial practices of past societies.
Jakub Witowski
doaj +1 more source
Femoral stem wear in cemented total hip replacement
, 2008 The great success of cemented total hip replacement to treat patients with end-stage osteoarthritis and osteonecrosis has been well documented. However, its long-term survivorship has been compromised by progressive development of aseptic loosening, and ...
Barrans, Simon +16 more
core +1 more source
Predicting wear of UHMWPE: decreasing wear rate following a change in direction [PDF]
, 2011 Computational tools are emerging as design tools for the development of total joint replacement with improved wear performance. The current wear models of polyethylene assume that wear is linearly proportional to sliding distance; however, it is ...
Render, Todd D. +9 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ARTIFICIAL JOINTS: THEIR TRIBOLOGY AND WEAR PARTICLE ANALYSIS [PDF]
, 2008 The wear, friction, lubrication and particle distribution of differently heat treated CoCrMo cast prostheses provided by the same supplier were analysed. Wear tests were conducted on both pin-on-plate and simulation rigs.
Kinbrum, Amy
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Le recyclage au Paléolithique moyen. Des bifaces et des nucléus utilisés comme percuteurs
Archéopages, 2010 The reuse of lithic artefacts and of material deriving from their manufacture from the Middle Palaeolithic onwards is a phenomenon that has been noted since the 1960s. Here we pursue the hypothesis that bifaces and cores were reused by Neanderthal people
Émilie Claud +3 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source