Results 121 to 130 of about 506,711 (266)
BMC GeriatricsBackground Social isolation poses a significant threat to the health of older adults. However, there has been a lack of attention to the relationship between Internet use and social isolation.
Qiyuan Huang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Examination of social network members’ influence on daily drinking: A pilot study
Addictive Behaviors ReportsObjective: Research on young adult alcohol use often overlooks the influence of specific social network members on daily alcohol use. This pilot study combined egocentric social network methods with a daily diary design to examine how network members ...
Matthew K Meisel +4 more
doaj +1 more source
The Use of Social Network in Daily Pediatric Practice and Education: Turkish Pediatric Atelier. [PDF]
Int J Pediatr, 2020 Gönüllü E +14 more
europepmc +1 more source
The use of social networks in learning
, 2022 Las redes sociales históricamente han sido consideradas espacios de socialización cuyo objetivo se centra en el ocio y la distracción, sin embargo, en la actualidad su uso va más allá y han incursionado en el contexto educativo. Por lo expuesto se ha planteado como objetivo de análisis el determinar el uso pedagógico que docentes y estudiantes les dan ...
Rivera Merino, Daniel +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source