Results 141 to 150 of about 5,877,092 (294)

Research on the safety value and use value [PDF]

open access: yesProceedings of the 2015 International conference on Engineering Management, Engineering Education and Information Technology, 2015
Xiaohong Chen, Chenyu Liu, Wei Liu
openaire   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

MEASURING USE VALUE FROM RECREATION PARTICIPATION

open access: yes
Recreation demand studies have traditionally utilized a two-step valuation method, estimating condtional recreation participation probabilities and then intensity of use decisions.
Whitehead, John C.
core  

Corporate social responsibility interactivity and fan loyalty: Exploring value-in-use in digital sports communities

open access: yes
Purpose: This study explores how corporate social responsibility (CSR) interactivity on social media affects value cocreation among sports fans and enhances the sustainable management of professional sports organizations.
Wang, Fong-Jia;Chiu, Weisheng;Cho, Heetae
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An integrative framework of value [PDF]

open access: yes
The concept of value has been discussed for over 2000 years with various nuanced meanings. It was a focus of concern for Plato and Aristotle, and Adam Smith (1776) dealt extensively with value in The Wealth of Nations.
Smith, Laura A., Ng, Irene C. L.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The determination of optimal value of the firm in the short and long run by fine tuning the debt ratio and payout ratio under the new Dutch income tax code

open access: yes, 2004
The optimal value of the firm under the new Dutch income tax reform act in 2002, is reconsidered in this discussion paper. Tax shield of debt-financing and the aggregate tax payments of its joint investors are simultaneously considered.
Renaud, Jan   +4 more
core  

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