Results 221 to 230 of about 463,209 (335)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Pharmaceutical Analysis of Inpatient Prescriptions: Systematic Observation of Hospital Pharmacists' Practices in the Early User-Centered Design Phase.

JMIR Hum Factors
Butruille J, Cirnat N, Alaoui M, Saracco J, Cousein E, Chaniaud N.   +5 more
europepmc   +1 more source

Development of a Predictive Dashboard With Prescriptive Decision Support for Falls Prevention in Residential Aged Care: User-Centered Design Approach. [PDF]

JMIR Aging
Silva SSM, Wabe N, Nguyen AD, Seaman K, Huang G, Dodds L, Meulenbroeks I, Mercado CI, Westbrook JI.   +8 more
europepmc   +1 more source

Using Eye Tracking as a Tool to Teach Informatics Students the Importance of User Centered Design [PDF]

, 2017
Heléne Gelderblom, Funmi Adebesin, Jacques Brosens, Rendani Kruger   +3 more
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

BMT Roadmap: A User-Centered Design Health Information Technology Tool to Promote Patient-Centered Care in Pediatric Hematopoietic Cell Transplantation [PDF]

, 2017
Lyndsey Runaas, David A. Hanauer, Molly E. Maher, Evan Bischoff, Alex Fauer, Tiffany Hoang, Anna Munaco, Roshun Sankaran, Rahael Gupta, Sajjad Seyedsalehi, Amy Cohn, Larry An, Muneesh Tewari, Sung Won Choi   +13 more
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Co-Design of a Depression Self-Management Tool for Adolescent and Young Adult Cancer Survivors: User-Centered Design Approach. [PDF]

JMIR Form Res
Murphy KM, Glock R, Victorson D, Reddy M, Birken SA, Salsman JM.   +5 more
europepmc   +1 more source

1F4-2 Fundamental research on user-centered train cab design

, 2015
Masaaki IKENO, Jun ONODERA, Yuich TAKEDA, Ken KUSUKAMI   +3 more
openalex   +2 more sources

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source