Results 61 to 70 of about 665,180 (356)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
User-centered virtual environment design for virtual rehabilitation
Journal of NeuroEngineering and Rehabilitation, 2010 Background As physical and cognitive rehabilitation protocols utilizing virtual environments transition from single applications to comprehensive rehabilitation programs there is a need for a new design cycle methodology.
Rizzo Albert A +2 more
doaj +1 more source
Understanding and Supporting the Design Systems Practice [PDF]
arXiv, 2022 Design systems represent a user interaction design and development approach that is currently of avid interest in the industry. However, little research work has been done to synthesize knowledge related to design systems in order to inform the design of tools to support their creation, maintenance, and usage practices.
arxiv
Critical Look at the User-Centered Design Competencies [PDF]
Proceedings of the 9th Nordic Conference on Human-Computer Interaction, 2016 Public sector services are going through an extensive digital reformation, which intends to improve the quality of these services. A user-centered design (UCD) approach and UCD skills are required if citizens are involved in the public e-services' development. In this paper we present a study in which we utilized the UCD Competency Model.
Kautonen, Heli, Nieminen, Mika, P.
openaire +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Applied Sciences, 2021 The medical device design process has a responsibility to define the characteristics of the object to ensure its correct interaction with users.
Fabiola Cortes-Chavez +2 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
User Centered Design Dalam Evaluasi Game “Reinhart and the Great Gate”
Teknika, 2020 Sebuah produk pasti memerlukan pengujian untuk mencapai kualitas produk sehingga layak untuk dipasarkan. Game sebagai produk digital, sebelum dapat dipasarkan tentu harus diuji dahulu. Ada banyak metode pengujian game yang dapat dilakukan.
Agnes Karina Prita Atmani +2 more
doaj +1 more source
A decision support environment for behavioral synthesis [PDF]
, 1991 We present a specification of a general environment for behavioral synthesis centered around the user/designer as the primary motivator for decisions in design development.
Gajski, Daniel D., Hadley, Tedd
core
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source