Results 71 to 80 of about 10,961,192 (275)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
User experience and user-centered design: multimedia design for cognition, affect & behaviour [PDF]
, 2014 Poster and poster presentation for internal/external KCO profiling ...
Braad, Eelco +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Extending theory for user-centered information systems: Diagnosing and learning from error in complex statistical data [PDF]
, 1997 Utilization of complex statistical data has come at great cost to individual researchers, the information community, and to the national information infrastructure.
Robbin, Alice, Frost-Kumpf, Lee
core +1 more source
Design and Implementation of User Centered Interface on Mobile Phone
Journal of Measurement Science and Instrumentation, 2010 Mobile device research has been increasing rapidly in Human Computer Interaction（HCI）recently.Following this trend,this paper proposes a user-centered interface,which has been designed,completely installed and independently run on a mobile phone.Video ...
Hoa-minh LE +2 more
doaj
To Improve the AcademySupporting instructors through large-scale curricular changes to cross-disciplinary programs such as general education is a complex challenge. In this case-based narrative, we describe how one large R1 university in the Southwest United States developed ...
Anuj Gupta +2 more
doaj +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Metáforas conceituais para design de hipermídias [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Design e Expressão Gráfica, Florianópolis, 2014A eficácia do design de hipermídias é dependente de muitos fatores, incluindo ...
Colusso, Lucas Franco
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
User centered design: In two iterations, this deliverable documents all activities and their results in the development of ImAc user scenarios and provides detailed use cases for the selected scenarios in order to derive system specification and later pilot scenarios.
Mica R. Endsley, Debra G. Jones
openaire +3 more sources