Results 91 to 100 of about 402,072 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The role of the user within the medical device design and development process: Medical device manufacturers' perspectives [PDF]

, 2011
Copyright @ 2011 Money et al.Background: Academic literature and international standards bodies suggest that user involvement, via the incorporation of human factors engineering methods within the medical device design and development (MDDD) process ...
Jennifer L Martin, Money, AG, Young, Terry, Kuljis Jasna, Money Arthur G, Young, T, Martin, Jennifer L., Craven, Michael P., Martin Jennifer L, Julie Barnett, Terry Young, Barnett, J, Young Terry, Arthur G Money, Barnett, Julie, Kuljis, J, Craven Michael P, Michael P Craven, Kuljis, Jasna, Money, Arthur G., Barnett Julie, Craven, MP, Martin, JL, Jasna Kuljis   +23 more
core   +1 more source

Research on user satisfaction with AIGC assisted museum scenario design

Scientific Reports
In the context of digital transformation, artificial intelligence generated content (AIGC) technology provides an innovative path for museum smart scene design, but existing research lacks a user-centered systematic framework.
Zhang Dongjiao, Zhang Yunlong, Jiang Xu
doaj   +1 more source

Penerapan Metode UCD (User Centered Design) Pada E-Commerce Putri Intan Shop Berbasis Web

Jurnal Teknologi dan Sistem Informasi, 2017
Pertumbuhan pesat pangsa pasar e-commerce di Indonesia memang sudah tidak bisa diragukan lagi. Dengan jumlah pengguna internet yang mencapai angka 82 juta orang atau sekitar 30% dari total penduduk di Indonesia, pasar e-commerce menjadi tambang emas yang
Intan Sandra Yatana Saputri, Mardhiah Fadhli, Ibnu Surya   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Considering the User in the Wireless World

, 2004
The near future promises significant advances in communication capabilities, but one of the keys to success is the capability understanding of the people with regards to its value and usage.
von Niman, B, Steinhage, A, Tscheligi, M, Anneroth, M, Visciola, M, Kalliokulju, S, Turner, T, Dainesi, E, Zucchella, A, Aftelak, A, Rantzer, M, Sasse, M, Crisler, K   +12 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Using formal models to design user interfaces a case study

, 2007
The use of formal models for user interface design can provide a number of benefits. It can help to ensure consistency across designs for multiple platforms, prove properties such as reachability and completeness and, perhaps most importantly, can help ...
Reeves, Steve, Steve Reeves, Judy Bowen, Bowen, Judy   +3 more
core