Results 111 to 120 of about 402,072 (304)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Using a Serious Game to Teach User-Centered Design
, 2019 The development of products with a good user experience requires a thorough understanding of the prospective users' behaviors, preferences, and needs.
Ferwerda, Bruce, Kiunsi, Domina
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Open, distributed and user-centered: Towards a paradigm shift in innovation policy [PDF]
Today's innovation policies ignore that innovation is increasingly open, distributed and user-centered. In this paper we introduce the user-centered model as an alternative paradigm of how innovation 'works'.
Jeroen de Jong, Eric von Hippel
core
Developing a Neuroarchitecture-based User Centered Design for Elementary Schools in Tehran
Ain Shams Engineering JournalNeuroarchitecture research investigates how environmental design affects the nervous system using quantitative methods. However, for user-centered design, qualitative research is equally important to actively involve users in the design process.
Beheshteh Gharaei +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Developing an engaging website: Combining technical and digital user-centered design strategies
This thesis delves into the development of an engaging website focusing on digital user-centered design strategies encompassing interactive environment, user interface scenography, interaction design, and user experience design principles.
Ahlach, Soukaina
core
E-Catalog Promotion of Fishermen Business Group with User Centered Design Method
JISA (Jurnal Informatika dan Sains)This research aims to design a promotional e-catalog for fishing business groups using the User Centered Design (UCD) method to improve the quality of their promotional services online.
Muchamad Fajri Amirul Nasrullah +4 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source