Results 131 to 140 of about 81,796 (259)

Methodological Framework for the Design and Implementation of a US Latine-Hispanic Digital Brain Health Program: User-Centered Design Approach. [PDF]

JMIR Form Res
Mohammed A, Ovalle-Eliseo S, Mohammed J, Islas Huerta G, Monserratt L, Andrade D, Garcia J, Kaufman R, Gutierrez M, Díaz-Santos M.   +9 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Understanding Graduate Students' Perspectives on Food Apps to Inform User-Centered Design: Explanatory Sequential Mixed Methods Survey Study. [PDF]

JMIR Form Res
Mokhtarnejad M, Fontes McCartin L.
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Development of iGET Living, a Digital Graded Exposure Intervention for Youth With Chronic Pain: Multiphase User-Centered Design and Pilot Study. [PDF]

JMIR Form Res
Harrison LE, Webster SN, Choate ES, Mayanja D, Jehl N, Darnall BD, Stinson JN, Bonnert M, Lalouni M, Wicksell RK, Simons LE.   +10 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Correction: Enhancing LGBTQ+ Inclusivity in an AI-Powered Sexual Health Chatbot: User-Centered Design Approach Through a Nonprofit and Academic Partnership. [PDF]

J Med Internet Res
Liem WW, Casline E, Lorenzo J, Gordon JD, Avila AA, Taylor A, Levitz N, O'Keefe MC, Shum K, Macapagal K.   +9 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

360°-Based Cognitive-Motor Training System for Older Adults With Cognitive Impairment: User-Centered Design and Evaluation Study. [PDF]

JMIR Aging
Bigotto F, Panigada J, Bruni F, Mancuso V, Cavedoni S, Stramba-Badiale M, Goulene KM, Pedroli E, Serino S.   +8 more
europepmc   +1 more source