Results 141 to 150 of about 14,169,783 (326)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Developing a Neuroarchitecture-based User Centered Design for Elementary Schools in Tehran

Ain Shams Engineering Journal
Neuroarchitecture research investigates how environmental design affects the nervous system using quantitative methods. However, for user-centered design, qualitative research is equally important to actively involve users in the design process.
Beheshteh Gharaei, Seyed Mohamad Sadegh Hayeri Zadeh, Mohammad Ghomeishi   +2 more
doaj   +1 more source

User-centered design in universal design resources?

, 2010
Studies have revealed usability problems with universal design resources (UDRs). In this paper, four UDR development cases are reviewed (Section 508 standards, Web accessibility guidelines, the British Standard on managing inclusive design, and Irish ...
Christopher Law (5042870), Paul Jaeger (20021847), Elspeth McKay (13622020)   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Designing Clinical Decision Support Systems (CDSS)—A User-Centered Lens of the Design Characteristics, Challenges, and Implications: Systematic Review

Journal of Medical Internet Research
Background Clinical decision support systems (CDSS) have the potential to play a crucial role in enhancing health care quality by providing evidence-based information to clinicians at the point of care.
Andrew A. Bayor, Jane Li, Ian A Yang, M. Varnfield   +3 more
semanticscholar   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Using a Serious Game to Teach User-Centered Design

, 2019
The development of products with a good user experience requires a thorough understanding of the prospective users' behaviors, preferences, and needs.
Ferwerda, Bruce, Kiunsi, Domina
core   +2 more sources

E-Catalog Promotion of Fishermen Business Group with User Centered Design Method

JISA (Jurnal Informatika dan Sains)
This research aims to design a promotional e-catalog for fishing business groups using the User Centered Design (UCD) method to improve the quality of their promotional services online.
Muchamad Fajri Amirul Nasrullah, Rina Yulius, Muhamad Sahrul Nizan, Siskha Handayani, Banu Failasuf   +4 more
doaj   +1 more source