Results 141 to 150 of about 520,790 (302)

Harmonizing design and desire: Unveiling user-centered requirements for university buildings

Results in Engineering
The design of university buildings plays a critical role in users' productivity, health, and behavior. The design should incorporate end users' and architects' perceptions to prevent decreased satisfaction, productivity, and health issues.
Mohamed Yasser Arafat, Ahmed Atef Faggal, Laila Khodeir, Tamer Refaat   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A user-centred approach to affective interaction [PDF]

, 2005
We have built eMoto, a mobile service for sending and receiving affective messages, with the explicit aim of addressing the inner experience of emotions.
Höök, Kristina, Ståhl, Anna, Sundström, Petra   +2 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]

, 2009
In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole, DUCHAMP, Robert, SONG, Heon   +2 more
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Designing gestures for affective input: an analysis of shape, effort and valence [PDF]

, 2003
We discuss a user-centered approach to incorporating affective expressions in interactive applications, and argue for a design that addresses both body and mind. In particular, we have studied the problem of finding a set of affective gestures.
Fagerberg, Petra, Höök, Kristina, Ståhl, Anna   +2 more
core   +1 more source

Chapter User-Centered Design

, 2017
The successful introduction and acceptance of novel technological tools are only possible if end users are completely integrated in the design process. However, obtaining such integration of end users is not obvious, as end‐user organizations often do not consider research toward new technological aids as their core business and are therefore reluctant
Doroftei, Daniela, Gancet, Jeremi, Serrano, Daniel, Cubber, Geert De, Wagemans, Rene, Matos, Anibal, Silva, Eduardo, Lobo, Victor, Cardoso, Guerreiro, Chintamani, Keshav, Govindaraj, Shashank   +10 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source