Results 121 to 130 of about 402,072 (304)

PERANCANGAN ULANG KEMASAN CUP KOPI INSTAN BERDASARKAN USER-CENTERED DESIGN

open access: yes, 2011
Kopi merupakan salah satu minuman yang digemari banyak orang. Bermacam-macam produk kopi instan dan kopi cair siap minum beredar di pasaran. Namun produk-produk instan ini belum menggunakan kemasan yang juga instan.
Vilia, Sutra Kusuma Dewi   +2 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Design and development of a user-centred digital library system: some basic guidelines

open access: yes, 2001
Beginning with an introduction and justifications for the need of user-centred digital library development, this paper outlines the architecture, the basic components and functionalities of a Digital Work Environment (DWE) that forms the basis of a user ...
Chowdhury, G.   +3 more
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Archive and Database Usability

open access: yes, 2017
Video recording of a presentation discussing user-centered design for language archives. This was presented during the afternoon session on "Archive and database usability" at the 2017 Symposium on Developing Infrastructure for Computational Resources on
Willis Oko, Christina
core  

Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]

open access: yes, 2009
In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

User Assemblages in Design: An Ethnographic Study

open access: yes
This thesis presents an ethnographic study of the role of users in user-centered design. It is written from the perspective of science and technology studies, in particular developments in actor-network theory, and draws on the notion of the assemblage ...
Wilkie, Alex, HASH(0x79501421a170)
core  

Home - About - Disclaimer - Privacy