Results 111 to 120 of about 10,961,658 (275)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Considering the User in the Wireless World [PDF]

, 2004
The near future promises significant advances in communication capabilities, but one of the keys to success is the capability understanding of the people with regards to its value and usage.
von Niman, B, Steinhage, A, Tscheligi, M, Anneroth, M, Visciola, M, Kalliokulju, S, Turner, T, Dainesi, E, Zucchella, A, Aftelak, A, Rantzer, M, Sasse, M, Crisler, K   +12 more
core  

UI/UX Design Planning of Ququ Bakery Application Using the User Centered Design (UCD) Method

Sistemasi: Jurnal Sistem Informasi
This study aims to design the user interface (UI) and user experience (UX) of a birthday cake ordering application for Ququ Bakery in Semarang, Central Java, using the User-Centered Design (UCD) approach.
Nabila Widya Anggraeni, Adi Nugroho
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Developing an engaging website: Combining technical and digital user-centered design strategies

This thesis delves into the development of an engaging website focusing on digital user-centered design strategies encompassing interactive environment, user interface scenography, interaction design, and user experience design principles.
Ahlach, Soukaina
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Using formal models to design user interfaces a case study [PDF]

, 2007
The use of formal models for user interface design can provide a number of benefits. It can help to ensure consistency across designs for multiple platforms, prove properties such as reachability and completeness and, perhaps most importantly, can help ...
Reeves, Steve, Steve Reeves, Judy Bowen, Bowen, Judy   +3 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Findings from the Workshop on User-Centered Design of Language Archives [PDF]

, 2016
This white paper comprehensively describes the insights that emerged from the Workshop on User-Centered Design of Language Archives. Key topics include a typology of language archives, the perspectives of stakeholder groups, and improving access to ...
Holton, Gary, Roth, Heather, Wasson, Christina   +2 more
core