Results 181 to 190 of about 515,631 (298)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development of an HPV 16 rapid test founded in user-centered design with primary care clinicians.

Anal Methods
Brennan LP, Hamacher F, Claure LA, Claure Dips AL, Sembian S, Balian LN, Piepho AD, Ermel AC, Linnes JC, Rodriguez NM.   +9 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Pragmatic Integration of User-Centered Design and Implementation Science: A New Methodological Approach for Clinical Decision Support Implementation in EHRs. [PDF]

Appl Clin Inform
Maw AM, Hoppe JA, Wagner NM, Mitchell J, Bean M, Trinkley KE.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Designing a Substance Misuse Data Dashboard for Overdose Fatality Review Teams: User-Centered Design Approach.

JMIR Hum Factors
Pisani M, Oguss MK, Dickson-Gomez J, Kostelac C, Parry A, Moss S, Salisbury-Afshar E, Patterson B, Spigner M, Gussick M, Krautkramer A, Gruenloh T, Safipour Afshar A, Gupta P, Mayampurath A, Afshar M.   +15 more
europepmc   +1 more source

Stress and Well-Being Intervention and mHealth Delivery Adaptation for Latinx Millennial Caregivers: Qualitative User-Centered Design Approach. [PDF]

JMIR Nurs
Thomas Hebdon M, Dupree GD, Hernandez J, Cuevas H, Thomas M, Burt S, Peterson N, Horner SD.   +7 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Tailoring Discharge Summaries to Health Care Providers' Needs (Part 1 of the Framework and Implementation of AI Tools Project): User-Centered Design Approach.

JMIR Med Inform
Deschepper M, Rogge H, Syx M, Colpaert K.   +3 more
europepmc   +1 more source

User-centered Design of an Adjunct Smartphone App to Reduce Cannabis Use among Youth Diverted from the Juvenile Legal System. [PDF]

Res Child Adolesc Psychopathol
Helseth SA, Piper KN, Dunne CJ, Kemp K, Barnett NP, Clark MA, Spirito A, Becker SJ.   +7 more
europepmc   +1 more source