Results 241 to 250 of about 101,383 (304)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Pharmaceutical Analysis of Inpatient Prescriptions: Systematic Observation of Hospital Pharmacists' Practices in the Early User-Centered Design Phase. [PDF]

JMIR Hum Factors
Butruille J, Cirnat N, Alaoui M, Saracco J, Cousein E, Chaniaud N.   +5 more
europepmc   +1 more source

Developing a Quick Isolation Bed Inquiry System During the COVID-19 Outbreak: User-Centered Design Approach Based on the Toyota Production System. [PDF]

JMIR Form Res
Lin CC, Shen JH, Chang SL, Kuo TC, Huang HL, Lin CP, Huang HM.   +6 more
europepmc   +1 more source

User-centered Design of an Adjunct Smartphone App to Reduce Cannabis Use among Youth Diverted from the Juvenile Legal System. [PDF]

Res Child Adolesc Psychopathol
Helseth SA, Piper KN, Dunne CJ, Kemp K, Barnett NP, Clark MA, Spirito A, Becker SJ.   +7 more
europepmc   +1 more source

A weather-forecast driven early warning system for wheat blast disease: User-centered design, validation, and scaling in Bangladesh and Brazil. [PDF]

Clim Serv
Krupnik TJ, Cunha Fernandes JM, Vargas F, Del Ponte EM, Hossain K, Kamal M, Billah M, Harun-Or-Rashid M, Hussain SG, Singh PK, Roy KK, Pizolotto CA, Kamal Khan MS, Pavan W, Faruq G.   +14 more
europepmc   +1 more source

Corrigendum to "The User-Centered Design of a Clinical Dashboard and Patient-Facing App for Gestational Diabetes". [PDF]

J Diabetes Sci Technol
europepmc   +1 more source