Results 71 to 80 of about 5,316,996 (342)

Farmers doing it for themselves: how farmer-inventors are frustrated by their interactions with the Agricultural Knowledge and Innovation System [PDF]

, 2018
Notwithstanding recent policy commitments to formally involve farmers in innovation through initiatives such as the European Innovation Partnership (EIP-AGRI), the traditional perspective of the policy and academic literature in Europe has been that ...
High, Chris, Lane, Andy, Macken-Walsh, Áine, O'Flynn, Trish   +3 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

From Producer Innovation to User and Open Collaborative Innovation [PDF]

, 2009
In this paper we assess the economic viability of innovation by producers relative to two increasingly important alternative models: innovations by single user individuals or firms, and open collaborative innovation.
Aghion P., Alchian A. A., Baldwin C. Y., Benkler Y., Blaxill M., Carliss Baldwin, Chandler A. D., Chesbrough H., Demsetz H., Dreyfuss R. C., Enos J. L., Eric von Hippel, Ford H., Gallini N., Gawer A., Gawer A., Ghosh R. A., Heald P. J., Hounshell D. A., Howe J., Kuhn T. S., Lakhani K. R., Lamoreaux N. R., Langlois R. N., Langlois R. N., Lüthje C., MacLeod C., Mansfield E., Mead C., Nelson R. R., Penrose E., Pine B. J., Pisano G. P., Schumpeter J. A., Scott W. R., Simon H. A., Simon H. A., Smith A., Stallman R. M., Strandburg K. J., Suh N. P., Teece D. J., von Hippel E., Williamson O. E., Woodward J.   +44 more
core   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The role of the user and the society in new product development [PDF]

, 2010
Within the knowledge-based economy several institutions are involved in product innovation processes. Literature study has shown that the most researched and cited are the industry-universitygovernment relations, presented in the Triple Helix model of ...
Duhovnik, Joze, Fain, Nusa, Moes, Niels
core  

Editorial : living labs and user innovation (December 2015) [PDF]

, 2015
Welcome to the January 2016 issue of the Technology Innovation Management Review – the second of two issues on the theme of Living Labs and User Innovation.
Huizingh, Eelko, Leminen, Seppo, McPhee, Chris, Schuurman, Dimitri, Westerlund, Mika   +4 more
core   +5 more sources

User Innovation as a Basis of Innovation Network Between Universities and Business

International Journal of Innovation, 2018
The paper aims at building a conceptual framework on how user innovation concept may be employed for the idea of creating innovation network between universities and business.
Z. Yordanova
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

From Idea Crowdsourcing to Managing User Knowledge [PDF]

Technology Innovation Management Review, 2013
This article explores how technology companies can benefit from user knowledge in product and service innovation beyond mere idea generation through crowdsourcing.
Risto Rajala, Mika Westerlund, Mervi Vuori, Jukka-Pekka Hares   +3 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source