Results 91 to 100 of about 2,901,480 (286)
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Game User-Interface Guidelines: Creating a set of Usability Design Guidelines for the FPS Game User-Interface [PDF]
This study reports on how usability principles can be implemented into a game development framework for the ingame user interface and head-up display.
Fricker, Helen
core +3 more sources
Jurnal Teknologi Informasi dan Ilmu KomputerSekitar 34% penduduk Aceh dari jumlah total angkatan kerja sebanyak 2.487.426 merupakan para pekerja pada sektor pertanian terutama pada sektor tanaman dan bahan makanan.
Ridwan Ridwan +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Clinical Biochemistry, 1986 The purpose of this monograph is to define the laboratory-user interface, to contrast two types of users (the clinician and the hospital administrator), to assess the value/cost relationship of the laboratory-user interface, and to decide whether or not this value/cost ratio is sufficiently high in all cases.
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
EVALUASI USABILITY WEBSITE PRODUK ORGANIK DENGAN METODE SYSTEM USABILITY SCALE
J@ti Undip: Jurnal Teknik IndustriPeran User Interface (UI) dan User Experience (UX) sangat penting dalam meningkatkan kemudahan penggunaan dan kepuasan pengguna website. Permasalahan utama penelitian ini adalah ketidakpastian faktor usability yang paling berpengaruh terhadap persepsi ...
Aisyah Sifa Nabila, Ratih Setyaningrum
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source