Results 41 to 50 of about 207,917 (308)
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Graphic user interface for synchrotron beamline
NOVASINERGIA, 2019 This research consisted of developing a graphical user interface in Python language for the reconstruction of images based on the propagation technique (PBI).
Jose Brito del Pino +3 more
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
User-Interface Modelling for Blind Users [PDF]
, 2008 The design of a user interface usable by blind people sets specific usability requirements that are unnecessary for sighted users. These requirements focus on task adequacy, dimensional trade-off, behaviour equivalence, semantic loss avoidance and device-independency.
Alonso Amo, Fernando +3 more
openaire +2 more sources
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
MODEL-BASED APPROACH TO USER INTERFACE DEVELOPMENT
Статистика и экономика, 2016 One of the main problems of model-driven user interface development approach is the complexity of the development of tools that maintain this methodology at all stages of the software lifecycle.
Anna А. Pupykina, Anna E. Satunina
doaj +1 more source
CHI '11 Extended Abstracts on Human Factors in Computing Systems, 2011 This document exposes the most relevant issues regarding the development of Distributed User Interfaces (DUIs) to present the specific features that are not covered by traditional development processes. A transversal approach to tackle these new aspects is also proposed.
Gallud, José +6 more
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source