Results 41 to 50 of about 3,312,093 (238)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

EXPERIMENTAL STUDIES OF THE INTERFACE DEVELOPED USING THE METHOD OF INFORMATION MODEL SYNTHESIS AT THE AUTOMATED WORKSTATION OF AIR TRAFFIC CONTROL MANAGER

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
Using the method of synthesis of the information model at the automated workstation of the air traffic control dispatcher, a fragment of the user interface at the automated workstation of the radar control dispatcher of the Minsk district control center ...
O. A. Kaptsevich, D. I. Rabchenok, K. Y. Ponomarev   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Languages for model-driven development of user interfaces: Review of the state of the art [PDF]

Yugoslav Journal of Operations Research, 2013
In model-driven user interface development, several models are used to describe different aspects of user interface when level of detail varies. The relations between the models are established through model transformations.
Jovanović Mlađan, Starčević Dušan, Jovanović Zoran   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Defining Recommendations to Guide User Interface Design: Multimethod Approach

JMIR Human Factors, 2022
BackgroundFor the development of digital solutions, different aspects of user interface design must be taken into consideration.
Ceci Diehl, Ana Martins, Ana Almeida, Telmo Silva, Óscar Ribeiro, Gonçalo Santinha, Nelson Rocha, Anabela G Silva   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Advanced User Interfaces for e-Learning

Je-LKS: Journal of E-Learning and Knowledge Society, 2009
This paper outlines an original approach to e-learning systems which integrates the most recent results in the feld of human-computer interaction. Notably it will show the applicability of multimodal, attentive, affective and perceptual user interfaces
Luca Bevilacqua, Nicola Capuano, Annunziata Cascone, Federico Ceccarini, Fabio Corvino, Ciro D'Apice, Ivano De Furio, Giovanna Scafuro, Gianluca Supino   +8 more
doaj   +1 more source