Results 41 to 50 of about 202,245 (312)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
THE DESIGN OF ADAPTIVE HYPERMEDIA INTERFACE FOR CHILDREN'S DIGITAL LIBRARY
Asia-Pacific Journal of Information Technology and Multimedia, 2013 There is a real requirement for greater interaction between children and the digital library which could be fulfilled by a good user interface. This study focuses upon web design principles and implements adaptive elements in the interface of the ...
Nurul Nadia Ab Rahaman +2 more
doaj +1 more source
ISML: an interface specification meta-language
, 2003 In this paper we present an abstract metaphor model situated within a model-based user interface framework. The inclusion of metaphors in graphical user interfaces is a well established, but mostly craft-based strategy to design.
Simon Crowle +3 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Físchlár on a PDA: handheld user interface design to a video indexing, browsing and playback system [PDF]
, 2001 The Físchlár digital video system is a web-based system for recording, analysis, browsing and playback of TV programmes which currently has about 350 users.
Murphy, Noel +5 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Applying Scenarios in the context of Specific User Design: Surgeon as an Expert User, and Design for Handicapped Children. [PDF]
, 2009 Organised by: Cranfield UniversityIn the context of specific user (surgery or handicap domain), the list of requirements is especially difficult to establish.
Rasoulifar, Rahi +5 more
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Approach Integration Design Sprints to Design Thinking in Learning Management System Sakattaku
Khazanah InformatikaThe Ministry of Education and Culture has introduced a new phase of its independent learning policy called the Movement Organization Program (POP). As a participant in POP, the Sakata Innovation Center Foundation offers a Saung Coding training program ...
Siti Nabilah Nida +2 more
doaj +1 more source
Designing a graphical interface for creativity support tools for designers: a case study [PDF]
, 2012 This study proposes a co-designing, iterative methodology to design graphical user interface for creativity support tools for designers. Given the high level of expectation from designers, the interface quality was one of the most challenging aspects of ...
AOUSSAT, Améziane +3 more
core +1 more source