Results 191 to 200 of about 8,236,850 (344)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Promoting User Involvement to Foster Technological Citizenship in the Digitizing Healthcare Domain. [PDF]

Sci Eng Ethics
Gardenier AM, Cramer I, van Est R.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Factors shaping user involvement in social and health services in Poland: the perspective of persons with disabilities. [PDF]

BMC Health Serv Res
Grabowska I, Wołowicz A, Naumiuk A, Kuleta-Hulboj M.   +3 more
europepmc   +1 more source

How People with Lived Experiences of Substance Use Understand and Experience User Involvement in Substance Use Care: A Synthesis of Qualitative Studies. [PDF]

Int J Environ Res Public Health, 2021
Selseng LB, Follevåg BM, Aaslund H.
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Examining impact of service user involvement: a follow-up study of user-led mental health service evaluation. [PDF]

Front Psychiatry
Näslund H, Grim K, Markström U.
europepmc   +1 more source

User Involvement in the Handover between Mental Health Hospitals and Community Mental Health: A Critical Discourse Analysis. [PDF]

Int J Environ Res Public Health, 2021
Jørgensen K, Rasmussen T, Hansen M, Andreasson K, Karlsson B.   +4 more
europepmc   +1 more source

Taking ownership: achieving real and meaningful user involvement [PDF]

, 2001
Alder, A
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source