Results 101 to 110 of about 501,868 (357)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Knowledge Work: Knowledge Worker Productivity, Collaboration and User Support. [PDF]

open access: yesJ. Univers. Comput. Sci., 2011
Knowledge Work: Knowledge Worker Productivity, Collaboration and User ...
Granitzer,Michael, Lindstaedt,Stefanie
openaire   +2 more sources

Automatic detection of accommodation steps as an indicator of knowledge maturing [PDF]

open access: yes, 2011
Jointly working on shared digital artifacts – such as wikis – is a well-tried method of developing knowledge collectively within a group or organization.
Moskaliuk, Johannes   +13 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

System quality, user satisfaction and end user development

open access: yes, 1999
Organisations rely heavily on user developed applications (UDAs) to support organisational decision making, but for the most part the satisfaction of the user developer is the sole indicator of application success.
Payne, C.   +6 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

An investigation of end user development success

open access: yes, 2002
User development of applications provides end users with an alternative to the traditional process of systems development by allowing them to solve job related problems by developing their own software applications.
McGill, Tanya Jane
core  

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