Results 121 to 130 of about 501,868 (357)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Mobile crowdsourcing - activation of smartphones users to elicit specialized knowledge through worker profile match [PDF]

, 2015
Oskar Jarczyk
openalex   +1 more source

End user development: What influences the relationship between satisfaction with tools and satisfaction with applications

, 2001
This study explored the possible role of four factors in the relationship between end user developers’ perceptions of their applications and their perceptions of the tools used to create them.
Loh, G., McGill, T.J., Wong, L., Seow, H.H., Lee, C.   +4 more
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Beyond the prompt: The Role of User Behavior in Shaping AI-misalignment and Societal Knowledge

Technology and Regulation
This research paper explores the concept of AI-misalignment, differentiating between perspectives of AI model designers and users. It delves into the notion of user-centric AI misalignment, breaking it down into three categories: user responsibility ...
Morraya Benhammou
doaj   +1 more source

Optimizing User Engagement in Enterprise Knowledge Management:Insights and Innovations from a Confluence Pages Project

, 2023
Arun Chandramouli
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

How AI-Driven User–Producer Interaction Fuels Interconnected Innovation: A Knowledge Exchange and Integration Perspective

Journal of Theoretical and Applied Electronic Commerce Research
In the rapid diffusion of artificial intelligence (AI), firms increasingly rely on AI to reshape user interactions, yet how such interactions translate into sustained innovation remains unclear.
Yang Yu, Miaomiao Li, Honglei Li, Kuanwei Wu   +3 more
doaj   +1 more source

Assessing the impact of user interaction with thesaural knowledge structures : a quantitative analysis framework

, 2002
Thesauri have been important information and knowledge organisation tools for more than three decades. The recent emergence and phenomenal growth of the World Wide Web has created new opportunities to introduce thesauri as information search and ...
Chowdhury, Gobinda, Shiri, A.A., Chowdhury, G., Revie, Crawford, Revie, C.W., Shiri, Ali Asghar   +5 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source