Results 141 to 150 of about 501,868 (357)

THE KNOWLEDGE USER PROFILE IN THE RURAL AREA OF ROMANIA [PDF]

open access: yesCES Working Papers, 2015
The economic entities today are struggling to find the most effective way of combining the resources they have, tangible or intangible, in order to produce and sale the most wanted products, their purpose is to gain and keep the highest share of the ...
Maria Claudia PREDA (DIACONEASA)
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Intelligent Support for Knowledge Sharing in Virtual Communities [PDF]

open access: yes, 2010
Virtual communities where people with common interests and goals communicate, share resources, and construct knowledge, are currently one of the fastest growing web environments.
Kleanthous Loizou, Styliani
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Understanding user behaviors and satisfaction in LLM-assisted tasks: prompting strategies and user knowledge states among college students

open access: yesInformation Research: An International Electronic Journal
Introduction. This study examines how users interact with large language models (LLMs), focusing on the interplay between users’ knowledge states and prompt strategies in shaping satisfaction. Method.
Tzu-Yun Chien   +2 more
doaj   +1 more source

Simplifying knowledge creation and access for end-users on the SW

open access: yes, 2008
In this position paper, we argue that improved mechanisms for knowledge acquisition and access on the semantic web (SW) will be necessary before it will be adopted widely by end-users.
Van Kleek, Max   +5 more
core  

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

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