Results 121 to 130 of about 330,656 (258)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

User Needs and Preferences for Multimodal Interaction in Social Robots for Later-Life Support: An Exploratory Survey and Conceptual Five-Layer Architecture. [PDF]

J Intell
Zhang Y, Liu Y.
europepmc   +1 more source

Grounded Theory-Based User Needs Mining and Its Impact on APP Downloads: Exampled With WeChat APP. [PDF]

Front Psychol, 2022
Chen T, Zhang C, Yang J, Cong G.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Designing AI-Enabled Video Monitoring Clinician Dashboard for Neuropsychiatric Symptoms: A Survey of User Needs. [PDF]

Am J Geriatr Psychiatry Open Sci Educ Pract
Gould CE, Davis CH, Schüz N, Lin FV, Samus QM, Terada T, Daniel M, Tee S, Adeli E.   +8 more
europepmc   +1 more source

Meeting Diverse User Needs [PDF]

, 2000
Richard E. Jones, David Beckett, Sally Fincher   +2 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation of an AI-Supported Nutrition Application (WiseFood) in a Living Lab Context: Protocol for a User Needs Assessment, Co-Design, and Feasibility Testing. [PDF]

JMIR Res Protoc
Walsh NM, Dunne P, O'Hara C, Štraus S, Kozic T, Antal E, Pózner V, Vig A, Szakos D, Kolidakis S, Skoutas D, Flynn AC, Timon CM.   +12 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Designing for aging on the move: a user-needs-driven approach to an optimized recreational vehicle (RV) scheme for older Chinese using an integrated Kano-AHP-QFD framework. [PDF]

Front Public Health
Jing Y, Yu S, Cheng Y, Yang X.
europepmc   +1 more source