Results 131 to 140 of about 330,656 (258)

User needs gathering for the design of information and communications technology-supported occupational stress management intervention: A quantitative study. [PDF]

Digit Health, 2022
Weerasekara M, Smedberg ÅB, Karunathilaka G, Sandmark H.   +3 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Nighttime fears in children: clinical characterisation and the user needs and preferences for a digital parent-led intervention. [PDF]

Child Adolesc Psychiatry Ment Health
Aji M, Datyner A, Gougeon J, Paravastu N, Champ SL, Lim CYS, Teng A, Hudson JL.   +7 more
europepmc   +1 more source

Chronic pain self-management in middle-aged and older adults: A collective intelligence approach to identifying barriers and user needs in eHealth interventions. [PDF]

Digit Health, 2022
O'Reilly PM, Harney OM, Hogan MJ, Mitchell C, McGuire BE, Slattery B.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Putting FUN into involvement: feedback user needs in the design of a mobile phone app for people with long-term conditions. [PDF]

Res Involv Engagem
Clayton DC, Hadjiconstantinou M, Ng AG, Andrade P, Bell J, Eyitemi FD, Hobson R, Masood A, Panagi M, Raza A, Tonga E, Worboys H, P-STEP User Group, Kadam U.   +13 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Using text mining to identify and prioritize user needs for digital mental health services on Chinese online platforms. [PDF]

Digit Health
Wu W, Jiang L, Zhang Q, Xu Y, Fang L, Dai S, Tian J, Yu H.   +7 more
europepmc   +1 more source

User needs

Analysis of specific user requirements and ...
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source