Results 191 to 200 of about 2,258,704 (301)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Bridging the Gap in Genomic Implementation: Identifying User Needs for Precision Nephrology. [PDF]

Kidney Int Rep
Kneifati-Hayek JZ, Zachariah T, Ahn W, Khan A, Kiryluk K, Mohan S, Weng C, Gharavi AG, Nestor JG.   +8 more
europepmc   +1 more source

Designing a mHealth clinical decision support system for Parkinson's disease: a theoretically grounded user needs approach. [PDF]

BMC Med Inform Decis Mak, 2020
Timotijevic L, Hodgkins CE, Banks A, Rusconi P, Egan B, Peacock M, Seiss E, Touray MML, Gage H, Pellicano C, Spalletta G, Assogna F, Giglio M, Marcante A, Gentile G, Cikajlo I, Gatsios D, Konitsiotis S, Fotiadis D.   +18 more
europepmc   +1 more source

User need report

A report on the user needs regarding the EasyReading framework.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Adjusting the 15-method to Danish general practice: identification of barriers, facilitators, and user needs. [PDF]

BMC Prim Care
Schøler PN, Søndergaard J, Rasmussen S, Nielsen AS.   +3 more
europepmc   +1 more source

End-user needs

Report with enduser needs and ...
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Maternal health applications: Qualitative findings of user needs. [PDF]

Digit Health
Babu S, Park N, Woodland G, Garcia N, Page W, Page R.   +5 more
europepmc   +1 more source

Indoor Navigation Systems for Visually Impaired Persons: Mapping the Features of Existing Technologies to User Needs. [PDF]

Sensors (Basel), 2020
Plikynas D, Žvironas A, Budrionis A, Gudauskis M.   +3 more
europepmc   +1 more source