Results 201 to 210 of about 2,258,704 (301)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Clinical Decision Support System for Addressing Health-Related Social Needs in Emergency Department: Defining End User Needs and Preferences. [PDF]

Appl Clin Inform
Mazurenko O, Hirsh AT, Harle CA, McNamee C, Vest JR.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Epidemic intelligence in Europe: a user needs perspective to foster innovation in digital health surveillance. [PDF]

BMC Public Health
Bouyer F, Thiongane O, Hobeika A, Arsevska E, Binot A, Corrèges D, Dub T, Mäkelä H, van Kleef E, Jori F, Lancelot R, Mercier A, Fagandini F, Valentin S, Van Bortel W, Ruault C.   +15 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Listening to children with lower limb loss: Rationale, design, and protocol for delivery of a novel globally applicable research toolkit-Prosthetic user needs, quality of life, pain, and physical function. [PDF]

PLoS One
Edgar CE, Ghidini C, Heang T, Favier CD, Gerrand CH, Furtado SH, Mayhew ER, Kheng S, Abu-Sittah GS, Bull AMJ.   +9 more
europepmc   +1 more source

Future user needs

Brief description: The deliverable identifies the potential drivers of future demand for road-space on major urban roads, associated with changes in socio-demographics, lifestyles and business models. It will do this through an international literature review (academic and grey literatures in different languages) and interviews with key stakeholder ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How Well Do Older Adult Fitness Technologies Match User Needs and Preferences? Scoping Review of 2014-2024 Literature.

J Med Internet Res
Tacca C, Vazquez Galvez A, Thompson IM, Bincalar AD, Tremmel C, Gomer R, Warner M, Freeman C, Schraefel MC.   +8 more
europepmc   +1 more source

Designing an app for alternative access assessments: Using interviews to uncover and define user needs. [PDF]

Assist Technol
Koester H, Fager S, Sorenson T, Jakobs E.   +3 more
europepmc   +1 more source