Results 141 to 150 of about 14,502,433 (244)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Perspective (Institute for Christian Studies)

, 1991
Sweetman Joins Faculty [Dr. Robert Sweetman], Zuidervaart pinch-hits at ICS, Touching Base out West: highlights lowlights and...[student ...
Klein, Reinder J., Postma, Gayle, Fernhout, Harry, Institute for Christian Studies   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

User Satisfaction With Assistive, Rehabilitation, and Training Technologies: Questionnaire Development and Content Validation Study. [PDF]

JMIR Rehabil Assist Technol
Cvjetičanin O, Marić I, Šarabon N.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

User innovation and the market [PDF]

This paper proposes a way of including in official statistics consumers as user innovators who modify or develop products for their own use. The issue addressed is the role of the market in the definition of innovation in the OECD/Eurostat Oslo Manual ...
Gault, Fred
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Quantifying the user experience : practical statistics for user research /

, 2012
"The primary purpose of this book is to provide a statistical resource for those who measure the behavior and attitudes of people as they interact with interfaces.
Lewis, James R.author., Sauro, Jeff,author.   +1 more
core  

Factors Influencing Adherence to Digital Lifestyle Interventions for Adolescents: Systematic Review and Meta-Analysis of Attrition. [PDF]

Interact J Med Res
Boumparis N, Studhalter O, de Riedmatten P, Yücel ID, Koutra K, Champion K, Molina-Barceló A, de Pablo-Pardo T, Kondylakis H, Schaub MP, Triantafyllidis A, Haug S.   +11 more
europepmc   +1 more source