Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
User perceptions of an artificial intelligence-based computer-aided detection system in colonoscopy: a single-center exploratory survey study. [PDF]
J Minim Invasive SurgKo SY +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Value in app store metadata and user reviews: A dual perspective on quality of Parkinson's and dementia apps. [PDF]
PLOS Digit HealthSchwaninger I +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Sentiment Analysis of Acceptance TVET Online Courses on the Skill Academy App from Google Play: Leveraging Text Mining with Comparison Machine Learning Model. [PDF]
F1000ResDarmono D +8 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Smart Objects for Clinical Rehabilitation and Education: A Scoping Review of Design, Sensing, and Validation. [PDF]
Sensors (Basel)Pugi L +3 more
europepmc +1 more source
Design and Evaluation of a Gamification-Based Mobile Application for Reporting Adverse Drug Reactions by Patients and Healthcare Professionals: A Pilot Usability Study in Diabetes Care. [PDF]
Drug Healthc Patient SafMahini K, Rahimi R, Vanaki Z.
europepmc +1 more source
Human-Centered Design of a Multistakeholder Reporting Dashboard for Disseminating HIV Implementation Research in the Ending the HIV Epidemic Initiative: Development and Formative Evaluation Study. [PDF]
JMIR Form ResJohnson TS +9 more
europepmc +1 more source