Results 241 to 250 of about 2,763,298 (299)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Applications of Smart Textiles for Ambulatory Electrocardiogram Monitoring: Scoping Review of the Literature. [PDF]

JMIR Cardio
Pedrini Schuch C, Chaves G, Moineau B, Bennett S, Pirbaglou M, Lobo EM, Alizadeh-Meghrazi M.   +6 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Personalized Glucose Management With AI: Pilot Study Using a Multiarmed Bandit Approach. [PDF]

JMIR Form Res
Hotta S, Kytö M, Koivusalo S, Heinonen S, Marttinen P.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A User-Centered Interface Design Framework for the DELONELINESS System in Older Adults: Design Indicator Development and Prioritization.

JMIR Hum Factors
Zhou Y, Rees J, Matcham F, Antonelli M, Ourselin S, Liu W.   +5 more
europepmc   +1 more source

T1D REACHOUT-A Mobile App to Deliver Peer-Led Mental Health Support to Adults Living With Type 1 Diabetes: Co-Design and Development Process. [PDF]

JMIR Diabetes
Lee S, Sidhu B, Johal P, Azhar A, Sujan J, Görges M, Tang TS.   +6 more
europepmc   +1 more source

FragmentFinder-a user-friendly, Windows-based tool for identifying and characterizing short RNAs excised from any noncoding RNA. [PDF]

NAR Genom Bioinform
DeMeis JD, Breaux CM, Powell AH, Campbell NJ, Houserova D, Huang J, Borchert GM.   +6 more
europepmc   +1 more source

A Scoping Review of Active Service User Involvement in Undergraduate Allied Health Professions Education. [PDF]

Health Expect
Shand C, Lynn JD, Pedlow K.
europepmc   +1 more source

The Development and Protocol for Testing a Co-Created Digital Intervention (Sentinel) to Improve Mental Well-Being and Help Manage and Prevent Trauma in First Responders.

JMIR Res Protoc
Cogan N, Kirk A, Graf C.
europepmc   +1 more source