Results 141 to 150 of about 5,339,657 (293)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
- Friends?... Fair enough. [PDF]
Social network analysis is one of the fields in the social sciences which went through a huge development in the last two decades. With the availability of newer tools and methods, in-depth analysis of huge networks became possible resulting in important
Attila Gulyás, László Áron Kóczy
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Emotional labour and its consequences in health-care setting [PDF]
The psychosomatic consequences of emotional labour are numerous. However, the most often debated one is burnout. Employers, through enforcing emotional norms onto employees expose their employees to emotional exhaustion, and in the long run ...
Kornélia Lazányi +1 more
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Prospects after the voting reform of the Lisbon Treaty [PDF]
The European Union used to make decisions by unanimity or near unanimity. After a series of extensions, with 27 member states the present decision making mechanisms have become very slow and assigned power to the members in an arbitrary way.
László Á. Kóczy
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The User Paradox in Technology Testing
Nordic Journal of Digital Literacy, 2011 Technology testing provides arenas for interaction between users and producers. In the experiments potential user needs and user-values regarding new technology are communicated to facilitate invention and diffuse innovation.
Per Hetland
doaj
Power indices expressed in terms of minimal winning coalitions [PDF]
A voting situation is given by a set of voters and the rules of legislation that determine minimal requirements for a group of voters to pass a motion.
Fabien Lange, László Á. Kóczy
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source