Results 81 to 90 of about 2,517,497 (197)

Evaluation of the Cytotoxic Activity of the Usnea barbata (L.) F. H. Wigg Dry Extract

Molecules, 2020
The secondary metabolites of lichens have proven to be promising sources of anticancer drugs; one of the most important of these is usnic acid, which is a phenolic compound with dibenzofuran structure that is responsible for the numerous biological ...
Violeta Popovici, Laura Adriana Bucur, Verginica Schröder, Daniela Gherghel, Cosmin Teodor Mihai, Aureliana Caraiane, Florin Ciprian Badea, Gabriela Vochița, Victoria Badea   +8 more
doaj   +1 more source

Developing a quantitative structure–property relationships (QSPR) model using Caco‐2 cell bioavailability indicators (BA) to predict the BA of phytochemicals

Journal of the Science of Food and Agriculture, Volume 105, Issue 12, Page 6850-6861, September 2025.
Abstract BACKGROUND The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (Papp) and efflux ratio, of 84 types of phytochemicals using Caco‐2 cell and to develop predictive model systems using machine learning with a quantitative structure–property relationship (QSPR) model ...
Kang‐Woo Lee, Dong‐Ho Lee, In‐Su Na, Jin‐Woo Kim, Na‐Yeon Lee, Jin‐Soo Park, Keunwan Park, Chau Hoang Bao Nguyen, Kyungsu Kang, Soon‐Mi Shim   +9 more
wiley   +1 more source

Revisitation of (+)-usnic acid reactivity, an interesting natural β-triketone

, 2012
One of the most investigated lichen substance is the secondary metabolite usnic acid, a yellow cortical pigment easily isolated from Cladonia, Usnea or Romalina species where it occurs up to 26%.1 Usnic acid is a benzofurandione, phloroglucinol like2,3 ...
B. Trucchi, L. Mesiano, L. Verotta
core   +2 more sources

Structural Elucidation and Free Radical Scavenging Activity of a new -Orsellinic Acid Derivative Isolated from the Lichen

Natural Product Communications, 2016
Rappiidic acid, a new o -orsellinic acid derivative, was isolated from the lichen Cladonia rappii . Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic ...
Tiago C.A. Lage, Lívia P. Horta, Ricardo M. Montanari, Jefferson G. Silva, Ângelo de Fátima, Sergio A. Fernandes, Luzia V. Modolo   +6 more
doaj   +1 more source

Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Effect of lobaric acid on Wnt/β‐catenin pathway in breast cancer. ABSTRACT Lichen secondary metabolites with many remarkable biological activities are used in cancer treatments due to their low side effects and high anticancer potential. In particular, these metabolites constitute an interesting research area in cancer treatments due to their potential
Şeyda Nur Kalın, Kübra Nur Bayındırlı, Emine Toraman, Şükran Günaydın, Fatmanur Keleş, Ahmet Altay, Harun Budak   +6 more
wiley   +1 more source

(+)-Usnic Acid Isolated from the Lichen Cladonia substellata Impairs Myocardial Contractility

, 2017
The scientific interest in (+)-usnic acid has grown because of its antitumor, cytotoxic, and antimicrobial activities as well as weight loss. However, overuse of usnic acid has been related with severe hepatotoxicity, making its use questionable. In this
Sílvia Mendonça, Adriano de Souza Araújo, Jader Cruz, Luiz da Silva, Carla de Vasconcelos, Danilo Roman-Campos, Eduardo Conde-Garcia, Robson Anjos-Neto, Ricardo Albuquerque-Júnior, José Menezes-Filho, Marília dos Santos Bezerra, Diogo Martins   +11 more
core   +1 more source

Usnic acid biological activity: history, evaluation and usage [PDF]

, 2017
Since Usnic acid (UA) was isolated from lichen metabolite in 1844, a lot of studies were conducted on it and now it became commercially available in the market.
Ahlam Abdulaziz Alahmadi, Alahmadi, Ahlam Abdulaziz   +1 more
core   +1 more source

Development and validation of a reliable LC–MS/MS method for quantitative analysis of usnic acid in Cladonia uncialis

BMC Research Notes, 2019
Objective The purpose of this study was to develop and validate a specific and sensitive liquid chromatography tandem mass-spectrometry method for quantification of usnic acid concentration in the lichen, Cladonia uncialis, suitable for detection of ...
Natalia Sveshnikova, Tao Yuan, Jamie M. Warren, Michele D. Piercey-Normore   +3 more
doaj   +1 more source

(R)-4-Acetyl-10-(2-chloro-1,3-thiazol-4-yl)-5,11,13-trihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.0^2,7]trideca-1(13),4,6,9,11-pentaen-3-one

Molbank
A novel usnic acid derivative with 2-chlorothiazole substituent was obtained by a three-step synthesis from usnic acid. The structure of the product was proved by a set of physical methods, including 1H, 13C, HRMS, HSQC, HMBC and IR spectroscopy.
Aleksandr S. Filimonov, Olga A. Luzina, Nariman F. Salakhutdinov   +2 more
doaj   +1 more source

Usnic Acid. III. Anhydromethyldihydrousnic Acid.

Chemical and Pharmaceutical Bulletin, 1963
Anhydromethyldihydrousnic acid, acetylation product of methyldihydrousnic acid, was proved to have structure (II). It was assumed that the reaction mechanism was not a simple acetylation reaction but it involved the fission and reformation of a-C-O-C- bond in the furan ring and the Dienone-Phenol rearrangement.
Takahashi, Kotaro, Miyashita, Shuichi
openaire   +2 more sources