Results 11 to 20 of about 21,102 (207)

Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. [PDF]

Protein Sci
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Adams JJ, Blazer LL, Chung J, Karimi M, Davidson T, Blair B, Waddle C, Hokanson CA, Bruce HA, Singer AU, Tombak EM, Gildemann K, Tamberg N, Kiiver K, Ustav M, Ma Y, Colombo L, Huang LJ, Michnick SW, Moe OW, Sidhu SS.   +20 more
europepmc   +2 more sources

Thiosulfonate-Derived BODIPY "Stick and Glue" Strategy for Fluorescent Thiol Labeling. [PDF]

Angew Chem Int Ed Engl
We present a powerful photochemical strategy for converting disulfide bonds into stable thioether linkages via a [1,2]‐sigmatropic rearrangement. By integrating this reaction into traditional methanethiosulfonate‐based thiol labeling, we enable light‐triggered stabilization of peptide and protein conjugates with enhanced robustness and versatility ...
Šálková L, Dunlop D, Tütüncü BB, Knejzlík Z, Slanina T.   +4 more
europepmc   +3 more sources

Local Maintenance and Genomic Diversity of Lymphocytic Choriomeningitis Virus in Natural Populations of House Mice in the Czech Republic Over a 24-Year Period. [PDF]

Zoonoses Public Health
ABSTRACT Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent‐borne zoonotic virus primarily infecting house mice. The virus can be highly pathogenic, particularly in immunocompromised individuals and in congenital infections. LCMV is distributed worldwide but shows local clustering, probably due to the highly structured populations of its ...
Jezkova I, Fornůsková A, Ďureje Ľ, Macholán M, Piálek J, de Bellocq JG.   +5 more
europepmc   +2 more sources

Nitrogen-Doped Borane Cluster Network for High-Performance Supercapacitors Under Universal pH Conditions. [PDF]

ChemSusChem
Nitrogen‐doped borane cluster network was prepared as a porous electrode material, featuring 1–2 nm micropores and specific surface area up to 626 m2 g−1. It delivers outstanding supercapacitor performance, reaching 607 F g−1 in a three‐electrode configuration and 354 F g−1 in an asymmetric supercapacitor device.
Udnoor A, Prabu S, Vinu M, Kloda M, Mahun A, Kobera L, Londesborough MGS, Chiang KY, Demel J.   +8 more
europepmc   +2 more sources

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector-Borne Zoonotic Pathogens, South Moravia, Czech Republic. [PDF]

Zoonoses Public Health
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Šikutová S, Mravcová K, Mendel J, Šebesta O, Sak B, Holubová N, Kváč M, McKee C, Adler PH, Otranto D, Rudolf I.   +10 more
europepmc   +2 more sources

The Cell Cycle Timing of Human Papillomavirus DNA Replication. [PDF]

PLoS ONE, 2015
Viruses manipulate the cell cycle of the host cell to optimize conditions for more efficient viral genome replication. One strategy utilized by DNA viruses is to replicate their genomes non-concurrently with the host genome; in this case, the viral ...
Tormi Reinson, Liisi Henno, Mart Toots, Mart Ustav, Mart Ustav   +4 more
doaj   +1 more source

MODELI REVIZIJE USTAVA

Pravni Vjesnik, 2020
U ovom radu, autor se bavi tipiziranjem načina mijenjanja aktualnih ustava u svijetu, polazeći od uloge i značaja subjekata ustavnih promjena u postupku revidiranja ustava.
Jasmin Hušić
doaj   +1 more source

Beyond contacts: The important role of the support region in protein complex assembly. [PDF]

Protein Sci
Abstract Protein–protein interactions (PPIs) are fundamental to nearly all cellular processes; however, elucidating the principles governing protein association into complexes remains a significant challenge. Previous studies have shown that protein–protein interfaces can be partitioned into distinct regions—core, rim, and support—that differ in ...
Miclot T, Timr S.
europepmc   +2 more sources

Application of lexical information in grammar: On the data of Czech verbs [PDF]

Južnoslovenski Filolog, 2013
The interplay between lexical information and the rules of grammar is demonstrated by selected morphological and syntactic phenomena from the domain of Czech verbs.
Panevova Jarmila
doaj   +1 more source

Martin Ritter, Poznáním osvobozovat budoucí. Benjaminova teorie pravdy

Reflexe, 2021
Book review: Martin Ritter, Poznáním osvobozovat budoucí, Benjaminova teorie pravdy, Praha (Filosofický ústav AV ČR, Oikúmené) 2018, 191 str.
Alena Roreitnerová
doaj   +1 more source