Results 61 to 70 of about 493,726 (266)

The uterine adenosarcoma with postoperative residual in a woman treated by total abdominal hysterectomy/bilateral salpingo‐oophorectomy: A case report and review of literature

Cancer Reports, 2023
Background In patients with uterine adenosarcoma, a total abdominal hysterectomy (TAH) with bilateral salpingo‐oophorectomy (BSO) is typically recommended as an initial treatment. There is no consensus on adjuvant therapies.
Pedram Fadavi, Maryam Garousi, Sepideh Soltani, Fatemeh Montazer, Maryam Abolhasani, Salar Asgari, Elahe Mirzaee   +6 more
doaj   +1 more source

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Philip R. Dash, Cartwright, JE, Whitley, GS, Ashton, SV, Philip N. Baker, Crocker, IP, Baker, PN, Guy St. J. Whitley, Ian P. Crocker, Mark Wareing, Wareing, M, Sandra V. Ashton, Judith E. Cartwright, Dash, PR   +13 more
core   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Frontiers in Immunology
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa.
Dorien Feyaerts, Marilen Benner, Gaia Comitini, Wijs Shadmanfar, Olivier W.H. van der Heijden, Irma Joosten, Renate G. van der Molen   +6 more
doaj   +1 more source

Neuroendocrinal, neurodevelopmental and embryotoxic effects of recombinant tissue plasminogen activator treatment for pregnant women presenting with acute ischemic stroke

Frontiers in Neuroscience, 2016
Thrombolysis with recombinant tissue plasminogen activator (rTPA) was the first evidence-based treatment approved for acute stroke. Ischemic stroke is relatively uncommon in fertile women but treatment is often delayed or not given. In randomized trials,
Anna eSteinberg, Anna eSteinberg, Tiago eMoreira, Tiago eMoreira   +3 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus [PDF]

, 2007
Premature labour (PTL) is the single most significant factor contributing to neonatal morbidity in Europe with enormous attendant healthcare and social costs. Consequently, it remains a major challenge to alleviate the cause and impact of this condition.
Bin Wang, Blanks, A, Andrew Blanks, Taggart, Michael, Taggart, M, Wang, B, Sanjay Kharche, Kharche, S, Holden, A, Taggart, Michael J., Wang, Bin, Blanks, Andrew M., Zhang, Henggui, Henggui Zhang, Holden, Arun, Kharche, Sanjay, Blanks, Andrew, Zhang, H, Michael Taggart, Arun Holden   +19 more
core   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

A potential diagnostic biomarker: Proteasome LMP2/b1i-differential expression in human uterus neoplasm [PDF]

, 2012
Uterine leiomyosarcoma (ULMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine ULMS
Nobuo Yaegashi, Akiko Horiuchi, Takuma Hayashi, Hiroyuki Aburatani, Susumu Tonegawa, Ikuo Konishi   +5 more
core  

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source