Results 111 to 120 of about 578,573 (268)

The HPV cellular transactivator Brn-3a can be used to predict cervical adenocarcinoma and squamous carcinoma precancer lesions in the developed and developing worlds [PDF]

, 2009
The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA.
Ndisang, D., Ashfaq Khan, Sindos, M., Lorenzato, F., Khan, A., Latchman, David S., Singer, A., Felipe Lorenzato, David S. Latchman, Daniel Ndisang, Michael Sindos, Albert Singer   +11 more
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Cytological features of uterine tumors resembling ovarian sex‐cord tumors in liquid‐based cervical cytology: a potential pitfall. Report of a unique and rare case

, 2019
Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype.
Bongiovanni, M., Ponti, A., Lucia Gherasimiuc, Massimo Bongiovanni, Maria Teresa Alvarez Flores, Mathevet, P., Bernier, Y., Alexandre Ponti, Estelle Dubruc, Patrice Mathevet, Yannick Bernier, Dubruc, E., Gherasimiuc, L., Alvarez Flores, M.T., Ponti A, Mathevet P, Bongiovanni M, Alvarez Flores MT, Gherasimiuc L, Dubruc E, Bernier Y   +20 more
core   +1 more source

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

A retrospective study on cervical intraepithelial lesions of low-grade and undetermined significance: evolution, associated factors and cytohistological correlation

São Paulo Medical Journal
CONTEXT AND OBJECTIVES: Cervical cancer is an important cause of morbidity and mortality throughout the world. There is some controversy about the factors that may be associated with infection by the human papillomavirus (HPV) that may favor or protect ...
Criseide Silva, Elia Cláudia Souza Almeida, Eliângela de Castro Côbo, Valéria Fátima Machado Zeferino, Eddie Fernando Cândido Murta, Renata Margarida Etchebehere   +5 more
doaj   +1 more source

Rectal wall dose-volume effect of pre- or post KUSHEN Ningjiaos relationship with 3D brachytherapy in cervical cancer patients

Radiation Oncology, 2019
Background The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos in cervical cancer patients and ...
Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang, Lei Gao   +8 more
doaj   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Metastatic Lung Adenocarcinoma to the Uterus Mimicking a Primary Uterine Malignancy: A Case Report [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Lung adenocarcinoma is the most prevalent subtype of non‐small cell lung cancer and exhibits a high tendency for distant metastasis. However, uterine metastasis with synchronous multiorgan involvement is extremely rare and prone to misdiagnosis due to atypical clinical presentations.
Sun P, Wang Y.
europepmc   +2 more sources

HMGA2 is a highly sensitive marker for DICER1‐related tumours

Histopathology, EarlyView.
Aims DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1‐related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent‐onset tumours.
Paul S. Thorner, Anne‐Laure Chong, Naciba Benlimane, Lili Fu, Marc R. Fabian, William D. Foulkes   +5 more
wiley   +1 more source

An Unusual Uterine Tumor With Signet Ring Cell Features.

, 2012
In 2004, a 56-year-old woman was diagnosed with Stage IA follicular lymphoma in a cervical lymph node biopsy. The patient experienced total remission after local radiation therapy.
Sarro, R., Bisig, B., Fiche, M., Achtari, C., Ketterer, N., Benhattar, J., de Leval, L., de Leval L, Bisig B, Ketterer N, Fiche M, Benhattar J, Sarro R, Achtari C   +13 more
core   +1 more source