Results 161 to 170 of about 110,820 (315)

Desempenho do exame citológico e da captura híbrida II no rastreamento de lesões intraepiteliais escamosas de alto grau em mulheres HIV+

Cadernos de Saúde Pública
As lesões intraepiteliais escamosas de alto grau (HSIL) são precursoras do câncer do colo do útero, com maior risco de ocorrência e desenvolvimento em mulheres HIV+.
Letícia Martins Raposo, Luciane Velasque, Paula Mendes Luz, Ruth Khalili Friedman, Andrea Cytryn, Angela Cristina Vasconcelos de Andrade, Tazio Vanni, Pedro E. A. A. Brasil, Fabio Russomano, Valdiléa Gonçalves Veloso, Beatriz Grinsztejn, Claudio José Struchiner   +11 more
doaj  

Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus [PDF]

, 2018
Background: Histologically, tumors of the anal region are either keratinizing (K) or non-keratinizing (NK) squamous cell carcinomas (SCCA). We hypothesized that these two variants might represent, not only morphologically, but also biologically ...
Allal, Abdelkarim, Bründler, Marie-Anne, Gervaz, Pascal   +2 more
core  

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, Volume 12, Issue 46, December 11, 2025.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report [PDF]

, 2017
Babb, Sheri, Divine, Laura M, Hagemann, Ian S, Mullen, Mary M, Powell, Matthew A   +4 more
core   +3 more sources

Role of Tryptophan Metabolism in Cancer

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui, Dandan Wang, Ye Zhang, Long Yuan, Yi Zhang, Xiaowei Qi   +5 more
wiley   +1 more source

The public policies and the attention to the uterine cervical neoplasm in the state of Mato Grosso - a critical approach

, 2009
Este estudo faz um levantamento de dados secundários, e aborda as condições atuais da atenção à saúde da mulher com câncer do colo do útero no Estado de Mato Grosso, com o objetivo precípuo de iniciar um diálogo entre estes números com o direito fundamental do ser humano: a saúde.
Villa, Maria Conceição da Encarnação, Pereira, Wilza Rocha   +1 more
openaire   +1 more source

Second Primary Cancer After Bladder Cancer: A Comprehensive Analysis of a National Cancer Registry

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Bladder cancer (BC) is one of the most common cancers and many patients will experience long‐term survival. Non‐urothelial second primary cancers (SPC) relatively frequently occur in the population of BC survivors. Methods Czech National Cancer Registry was the principal data source for this study.
Tomas Buchler, Lucie Pehalova Kusova, Alina Pirshtuk, Jan Muzik, Marek Babjuk, Ladislav Dusek   +5 more
wiley   +1 more source

Diagnosis of cervical cancer by a urine test

Journal of Education, Health and Sport, 2019
Cervical cancer is the fourth most common malignant tumor among women in the world. However, 90% of deaths occur in developing countries. Tumor pathogenesis is associated with exposure to high-risk human papillomavirus (hrHPV), most often 16 and 18 ...
Anna Małgorzata Łopuszyńska, Bartłomiej Pawlicki, Mateusz Maciej Pawlicki, Karol Lorenc, Magdalena Kozioł, Zofia Misztal   +5 more
doaj  

Unusual Presentation of Subcutaneous Panniculitis‐Like T‐Cell Lymphoma

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare variant of primary cutaneous T‐cell lymphoma primarily affecting subcutaneous adipose tissue and mimicking lobular panniculitis. It often presents with erythematous subcutaneous nodules or plaques, and diagnosis can be challenging due to its diverse clinical manifestations.
Mona Alkallabi, Hend Alotaibi, Khalid Nabil Nagshabandi, Reem Bin Idris, Amal H. Abualola, Naif Ahmed Alshehri, Ahmed Alhumidi   +6 more
wiley   +1 more source