Results 191 to 200 of about 702,089 (378)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Single‐Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions

Cancer Science, EarlyView.
This study is the first to identify a novel neutrophil subpopulation, N4, that is closely associated with the progression of cervical cancer. Characterized by high PLAU expression and specific interactions with tumor cells, N4 neutrophils were shown to promote tumor growth and immune modulation.
Ze Wang, Liang Zhuang, Shiyi Liu, Canhui Cao, Shimin Chen, Nan Yu, Xiaoyuan Huang, Tao Zhang   +7 more
wiley   +1 more source

The Evolving Molecular Landscape of Uterine Mesenchymal Tumors: Diagnostic and Therapeutic Implications. [PDF]

Cancers (Basel)
Sun T.
europepmc   +1 more source

Tumor‐Associated Macrophage‐Derived CXCL1 Promotes Endometrial Cancer Progression Through the CXCR2/NF‐κB Pathway

Cancer Science, EarlyView.
CXCL1 secreted by M2 macrophages induced EMT of EC cells through the CXCR2/NF‐κB pathway; CXCR2 expression was predominantly observed in the epithelial compartment, whereas CXCL1 expression was primarily localized in the stromal region; Neutralization of M2 macrophage‐secreted CXCL1 and inhibiting the NF‐κB pathway can inhibit EC progression in vivo ...
Ruiqi Xia, Dingtian Qi, Boshu Ji, Yisheng Dai, Xianchao Kong   +4 more
wiley   +1 more source

Refining Tumor Mutational Burden as a Predictive Biomarker for Pembrolizumab: A Real‐World Analysis in Japanese Patients

Cancer Science, EarlyView.
In this study, we investigated the predictive value of tumor mutational burden (TMB) for assessing the efficacy of pembrolizumab in a Japanese cohort. We analyzed real‐world data from 63,952 patients registered in the C‐CAT database who underwent comprehensive genomic profiling, and evaluated the therapeutic efficacy of pembrolizumab in 1899 of these ...
Tomoyo Yasuda, Mio Yumura, Azusa Hamasaki, Tongyi Fei, Takashi Kubo, Hitoshi Ichikawa, Takashi Kohno, Kuniko Sunami   +7 more
wiley   +1 more source

Diet-SRNet: A Novel DieT Transformer-Based Model for Accurate Uterine Neoplasm Classification [PDF]

Asma’a Al-Mnayyis, Mohammad Amin, Hamad Yahia Abu Mhanna, Rawan Eimad Almahmoud, Rola Madain, Eman Hussein Alshdaifat, Hanan Akhdar, Hasan Gharaibeh, Salem Alhatamleh, Ahmad Nasayreh, Mohammad A. Gharaibeh   +10 more
openalex   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Benign Uterine Corpus Neoplasm [PDF]

, 2020
openaire   +1 more source

Concurrent benign leiomyomas in heart, lung, and abdomen: a case report. [PDF]

J Med Case Rep
Afshar H, Babaheidarian P, Ghalamkari M, Pazoki M, Sadeghi SH, Olya M.   +5 more
europepmc   +1 more source

Detection of the Heterozygous Recurrent MAX p.(Arg60Gln) Variant in Two Females Confirms and Expands the Phenotypic Spectrum of Polydactyly–Macrocephaly Syndrome

Clinical Genetics, EarlyView.
We identified a recurrent heterozygous MAX c.179G>A:p.Arg60Gln variant in two unrelated females affected with the emerging phenotypes of MAX‐associated polydactyly‐macrocephaly syndrome. We propose that genitourinary abnormalities, including Mayer–Rokitanski–Kuster–Hauser syndrome in one individual, are an expansion of the known phenotypes associated ...
Iftekhar A. Showpnil, Neta Feinstein‐Goren, Lior Greenbaum, Ortal Barel, Daniel C. Koboldt, Samantha A. Brugmann, Kathryn Nicole Weaver, Anne Slavotinek, Ben Pode‐Shakked, Rolf W. Stottmann   +9 more
wiley   +1 more source